Erythema dyschromicum perstans erythema dyschromicum perstans novick, nelsonlee. Erythema dyschromicum perstans northwestern scholars. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin, which usually occurs from age 5 years through. Erythema dyschromicum perstans edp is a rare, chronic, pig mentary disorder with unknown etiology 1. We have experienced two cases of edp in children aged 2 and 3, both exceptionally younger than the previously reported cases. The pigmentary disorder has never been reported in patients during pregnancy. Erythema dyschromicum perstans showing resolution in an adult. Apr 30, 2018 erythema dyschromicum perstans edp also known as ashy dermatosis refers to a persistent local redness of the skin. Explore more on erythema dyschromicum perstans below. The term erythema dyschromicum perstans was coined by venezuelan physician marion sulzberger to highlight the word erythema because an erythematous border is observed in the early lesions and also to suggest the variety and persistence of the dyschromia.
Lesions also may be surrounded by a pale halo that serves to accentuate the ashen. We wish you a cure and never get sick of this disease. Erythema dyschromicum perstans bioinformatics tool laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on cocitations. Jul 18, 2019 in south america, another name, erythema chronicum figuratum melanodermicum, also is used. Dermatopathology reference describes erythema dyschromicum perstans ashy dermatosis histopathology including histologic features and. We report an 8yearold east indian boy with erythema dyschromicum perstans. Erythema dyschromicum perstans is a recently described dermatosis that appears to be a distinct and diagnosable entity. Erythema dyschromicum perstansashy dermatosis causes. Erythema dyschromicum perstans and lichen planus pigmentosus. Erythema dyschromicum perstans in an 8yearold indian child. The rim of erythema that appears during the inflammatory phase of the disorder distinguishes it from other disorders of hyperpigmentation. Coexistence of erythema dyschromicum perstans and vitiligo acta.
Erythema dyschromicum perstans ashy dermatosis and. Erythema dyschromicum perstans jama dermatology jama. Dermatosis cenicienta pdf new pdf download service. Druginduced and postinflammatory hyperpigmentation may last for many months after the offending drug or dermatitis has been eliminated. Some authors include erythema dyschromicum perstans as a variant of lichen planus because of the many clinical and histopathologic similarities between the diseases,z3 we describe a patient with erythema dyschromicum perstans preceded by lichen planus and. However, the border can be difficult to discern in darker skinned populations 12. Erythema dyschromicum perstans or ashy dermatosis is a chronic hyperpigmentary disease of unknown etiology. Erythema dyschromicum perstans also known as ashy dermatosis, and dermatosis cinecienta is an uncommon skin condition with peak age of onset being young adults, but it may also be seen in children or adults of any age. Combination therapy with prednisone and isotretinoin in early. Chlorothalonil exposure among banana farm workers is another possible cause of edp. Mar 18, 2020 many therapeutic options are available for erythema dyschromicum perstans edp, but few have been effective, except for clofazimine. The photos of erythema dyschromicum perstans below are not recommended for people with a weak psyche.
Dermis erythema dyschromicum perstans information on. Mar 18, 2020 erythema dyschromicum perstans ashy dermatosis is a distinct and somewhat controversial cutaneous eruption that may be best regarded as a form of lichen planus or lichen planus actinicus. Lesions also may be surrounded by a pale halo that serves to. These are the options to access the full texts of the publication piel. Many therapeutic options are available for erythema dyschromicum perstans edp, but few have been effective, except for clofazimine.
Erythema dyschromicum perstans edp is an uncommon, somewhat dubious cutaneous eruption of unknown etiology first described by ramirez in 1957. It is a form of acquired dermal macular hyperpigmentation. Erythema dyschromicum perstans and ashy dermatosis the only significant difference between erythema dyschromicum perstans and ashy dermatosis has been the presence of a palpable erythematous border measuring 12 mm in width in the early stages of the former 12,19. The following list of conditions have erythema dyschromicum perstans or similar listed as a symptom in our database. Erythema dyschromicum perstans is a slowly progressive acquired dermatoses characterized by macular hyperpigmentation. Erythema dyschromicum perstans and hepatitis c virus. This computergenerated list may be inaccurate or incomplete.
Aliaga, ashy dermatosis in an hiv antibodypositive patient, acta dermatovenereologica, vol. In adults, erythema dyschromicum perstans is more prevalent in the latin american and asian population. The histopathology showed pigment incontinence, accompanied. Erythema dyschromicum perstans is a dermal pigmentation seen on the trunk and proximal extremities, most commonly presenting in darkskinned hispanics.
Erythema dyschromicum perstans in prepubertal children. Two patients with having characteristic asymptomatic and slowly progressive, slategrey macular lesions with distinct red borders involving the face, neck, upper trunk and. Clinically, the condition is characterized by slowly progressive, symmetrical gray brown to blue gray macules, sometimes with an erythematous or elevated border, which is seen most commonly over the face, neck, trunk, and proximal arms. Acd az of skin erythema dyschromicum perstans and lichen. Lee, ashy dermatosis erythema dyschromicum perstans induced by omeprazole. We present a case of edp in an adult that cleared significantly after 6 years. Erythema dyschromicum perstans edp is a rare disorder characterized by asymptomatic, slowly progressive, ashgray macular pigmentation of the skin which usually occurs from age 5 through adult life. It is a chronic form of erythema multiforme in which the relapses recur so persistently that the eruption is almost permanent. Erythema dyschromicum perstans edp is an acquired, generalized dermal hypermelanosis of unknown etiology. Learn the causes, symptoms, differential diagnosis and treatment. Sep 20, 2018 erythema dyschromicum perstans and lichen planus. What is erythema dyschromicum perstans erythema dyschromicum perstans is a form of acquired dermal macular hyperpigmentation characterised by wellcircumscribed round to oval or irregular patches on the face, neck and trunk that are grey in colour. Dec 20, 20 history a young adult man presented with an asymptomatic wide spread macular slategrey hyperpigmentation involved mainly the torso of one year duration. Erythema dyschromicum perstans also known as ashy dermatosis, and dermatosis cinecienta is a skin condition with age of onset almost always before 40 years old, characterized by skin lesions that are usually symmetrical and generalized.
Erythema dyschromicum perstans ashy dermatitis entered by. Erythema elevatum diutinum is a rare form of necrotizing vasculitis which affects the skin covering joints fingers, toes, knees, elbows, wrists, ankles and other areas in some cases. Erythema dyschromicum perstans, international journal of. The etiology and clinical course in children is poorly defined. Erythema dyschromicum perstans edp is a disorder of pigmentation that is characterized by gray or bluebrown macules or patches in individuals with fitzpatrick skin types iiiv chang et al. Erythema dyschromicum perstans can be cosmetically distressing and socially embarrassing, especially if the lesion occurs in a visible area such as the face 1, 21. Histopathological findings demonstrate lichenoid dermatitis with vacuolization of basal cells, colloid bodies, and a moderate infiltrate of lymphocytes in the papillary. Erythema dyschromicum perstans is also called ashy dermatosis of ramirez, because of.
Ashy dermatosis, lichen planus pigmentosus and pigmented. It is characterized by disseminated macular lesions of an ashy gray color. Erythema dyschromicum perstans edp is an acquired hyperpigmentation disorder characterized by asymptomatic, polycyclic, irregularly. It is an acquired, chronic, idiopathic hypermelanosis of longstanding evolution that is characterized by blue. Erythema dyschromicum perstans erythema dyschromicum perstans novick, nelson lee. Erythema dyschromicum perstans, clinical picture 4010 erythema dyschromicum perstans, clinical picture 4011 erythema dyschromicum perstans, clinical picture 40 histology vacuolar degeneration of the basal layer, superficial lymphocytic infiltrate. The etiology of edp is unknown, but many associations have been described. Clinical syndrome of unknown origin characterized by a progressive bluish to ashgrey hyperpigmentation. It initially consists of the formation of firm papules andor nodules on the back of the hands which are yellow or pink in color. The terms lichen planus pigmentosus lpp, erythema dyschromicum perstans edp and idiopathic eruptive macular pigmentation iemp are names given to pigmentary disorders and often used interchangeably. A, schering plough athens, greece, 3 mu thrice weekly subcutaneously for 12 months, with additional topical steroid application. Erythema dyschromicum perstans in pregnancy rather s, yaseen. Downloaded free from on friday, september 04, 2015. Erythema dyschromicum perstans in early childhood md.
In adults, edp has a slow onset and is unlikely to resolve spontaneously. Erythema dyschromicum perstans and lichen planus jama. These changes were consistent with a diagnosis of erythema dyschromicum perstans edp. A report of three cases, international journal of dermatology, vol. Erythema dyschromicum perstans is a form of acquired dermal macular hyperpigmentation characterised by well circumscribed round to oval or irregular patches on the face, neck and trunk that are grey in colour. Erythema dyschromicum perstans ashy dermatosis and related. Two patients with having characteristic asymptomatic and slowly progressive, slategrey macular lesions with distinct red borders involving the face, neck, upper trunk and limbs. It occurs in adults, with some isolated cases and small series occurring in prepubertal children. It was not associated with any cutaneous or systemic disease.
Dec 14, 2018 erythema dyschromicum perstans edp is an uncommon, somewhat dubious cutaneous eruption of unknown etiology first described by ramirez in 1957. Lichen planus is a welldescribed entity of unknown cause and various presentations. Erythema dyschromicum perstans article about erythema. For more information on how to use laverne, please read the how to guide. Cutaneous mastocytosis must be distinguished from ashy dermatitis or erythema dyschromicum perstans, nodular scabies, neurofibromatosis, juvenile english pro pts in pair.
See the analysis of the prevalence of 4 causes of erythema dyschromicum perstans conditions listing medical symptoms. It was later called erythema dyschromicum perstans to highlight the erythematous halo around pigmented macules. It is an acquired, chronic, idiopathic hypermelanosis of longstanding evolution that is characterized by bluegray color macules that look like ash. Erythema dyschromicum perstans edp is a rare cutaneous eruption of unknown etiology that often resolves in prepubertal children but is generally thought to persist in adults. It clinically pre sents with oval to round, gray, blue. The condition has very rarely been reported in prepubertal. Erythema dyschromicum perstans, a rare dermatosis of obscure etiopathogenesis and significant cosmetic morbidity, have no satisfactory treatment. Topical tarolimus provides an effective and safe alternative therapeutic option in erythema dyschromicum perstans. A variety dermatosis cenicienta predisposing factors have been cited. Our dermatology online original article ashy dermatosis. Erythema anulare centrifugum eac, is a descriptive term for a class of skin lesion presenting redness in a ring form anulare that spreads from a center centrifugum. Variable components include erythema and papulation. Clinically it presents as asymptomatic, ashengrayblue macules of varying sizes, most commonly on the trunk and proximal extremities.
Lichen nitidus lichen striatus lichen ruber moniliformis gianotticrosti syndrome erythema dyschromicum perstans eritrodermia eruptive macular pigmentation keratosis lichenoides chronica kraurosis vulvae lichen sclerosus lichenoid dermatitis lichenoid reaction of graftversushost disease. Erythema dyschromicum perstans ashy dermatosis jama. Erythema dyschromicum perstans is a distinctive appearing dermatosis belonging to the erythema perstans group. The nosologic identity of edp has been challenged repeatedly as the number of patients with concurrent edplike eruptions and lichenoid disorders has increased. The condition was accompanied by intestinal parasitism, control of which produced remission of the active skin lesions. History a young adult man presented with an asymptomatic wide spread macular slategrey hyperpigmentation involved mainly the torso of one year duration.
In south america, another name, erythema chronicum figuratum melanodermicum, also is used. In one series of 8 patients, 7 had a good or excellent response to clofazimine administered either 100 mg every other day to patients weighing less than 40 kg or 100 mg every day to patients weighing more than 40 kg. Some consider erythema dyschromicum perstans which is also known as ashy dermatosis as a macular variant of lichen planus. Sep 27, 2018 erythema dyschromicum perstans edp is a disorder of pigmentation that is characterized by gray or bluebrown macules or patches in individuals with fitzpatrick skin types iiiv chang et al. Erythema dyschromicum perstans definition of erythema. The first case to be reported in the united states is described. Automatic update in citescore measures average citations received per document published. The lesions are usually distributed symmetrically on both sun and nonsunexposed areas including the trunk 69. Erythema dyschromicum perstans in pregnancy rather s. Ashy dermatosis definition of ashy dermatosis by medical.
Erythema dyschromicum perstans edp is a rare disorder of pigmentation that is most common in hispanic patients. Erythema dyschromicum perstans is also called ashy dermatosis of ramirez. From the department of dermatology, mount sinai school of medicine, new vork, new york ore than 25 years ago, ramirez described the first cases of erythema dyschromicum perstans edp. Two patients with having characteristic asymptomatic and slowly progressive, slategrey macular lesions with distinct red borders involving the face, neck, upper trunk and limbs were diagnosed clinicopathologically as. Participation is free and the site has a strict confidentiality policy. Many different terms have been used to classify these types of lesions and it is still controversial on what exactly defines eac. Erythema dyschromicum perstans ashy dermatosis is a distinct and somewhat controversial cutaneous eruption that may be best regarded as a form of lichen planus or lichen planus actinicus. Erythema dyschromicum perstans edp is a cutaneous pigmentary disturbance originally considered to be a variant of erythema perstans. The list of acronyms and abbreviations related to edp erythema dyschromicum perstans.